The First Street Strategic Regeneration Framework (SRF) is a comprehensive masterplan which sets out the development potential of First Street Manchester and the ribbon of sites addressing the opposite side of Medlock Street. A key aspect of the SRF is how the masterplan can deliver sustainable economic growth whilst reconnecting First Street and Medlock Street to its surrounding context of River street, Oxford Road, Hulme, The University corridor and the City Centre.

A critical ambition of the Framework for First Street is the delivery of high quality, coordinated public realm spaces, linkages and connections to support improved accessibility to, and through the First Street neighbourhood for pedestrians, cyclists and public transport. It highlights the importance of the public realm and connectivity to and across the area to creating a sense of place for the neighbourhood.

The neighbourhood now incorporates commercial office space, new homes, student facilities, theatres, cinemas and green infrastructure.

Jon Matthews Architects are the masterplanners for the SRF and Architects for the buildings No. 9 and 10 First Street, One City Road, One Medlock Street, 10-12 Whitworth Street and Axis within the masterplan. This represents over 2.2 million ft² of mixed use buildings either completed or with a detailed planning consent.